کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5157752 1500597 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel photopolymerizable derivative of hyaluronan for designed hydrogel formation
ترجمه فارسی عنوان
یک ترکیب مشتق شده از فایبرگلاسهای هیالورونان برای تشکیل هیدروژل طراحی شده
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
A new photopolymerizable derivative of hyaluronan (methacrylhydrazide-HA, MAHA) was prepared by carbodiimide chemistry. The reaction conditions were optimized for molecular weight (Mw), reaction time and amount of reagents with a degree of methacrylation (DM) ranging from 2% to 58%. Methacrylhydrazide-HA was hydrolytically stable (PBS, 7 days, 37 °C) in contrast to commonly used methacrylester analoque (23% hydrolyzed). MAHA readily photopolymerized into densely crosslinked hydrogels under physiological conditions. The varied DM, Mw, irradiation time (texp) and macromer concentration in photocrosslinking afforded hydrogels with different physical (swelling ratio, degradation rate) and mechanical properties (stiffness, toughness). Three-dimensional fabrication and surface patterning of MAHA hydrogels were demonstrated by photolithography and light mediated micromolding. A live-dead assay with skin fibroblasts showed convenient biocompatibility of MAHA (16%, 116 kDa) for potential scaffolding applications in tissue engineering and regenerative medicine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 161, 1 April 2017, Pages 277-285
نویسندگان
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