Hispidacine, an unusual 8,4′-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn.

Phytochemical investigation of a Malaysian sample of Ficus hispida Linn. led to isolation of an unusual 8,4′-oxyneolignan-alkaloid, hispidacine, and two phenanthroindolizidine alkaloids, hispiloscine and (+)-deoxypergularinine. Hispidacine induced vasorelaxant activity in rat aorta, while hispiloscine showed antiproliferative activities against four human cancer cell lines.