Sterols with antileishmanial activity isolated from the roots of Pentalinon andrieuxii

► Altogether 20 compounds were isolated and characterized from Pentalinon andrieuxii. ► Pentalinonsterol (1) and pentalinonside (2) are elucidated as hither to unknown sterol derivatives. ► Compound 1 and five known sterols were found to exhibit in vitro antileishmanial activity. ► This is the first time that sterols were reported as leishmanicidal principles of P. andrieuxii.