کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5209921 1503084 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enzymatic synthesis of collagen peptide-carboxymethylated chitosan copolymer and its characterization
ترجمه فارسی عنوان
سنتز آنزیمی کوپلیمر کیتین کپسول کربوکسی متیل شده و خصوصیات آن
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Collagen peptide grafted carboxymethylated chitosan was synthesized by using microbial transglutaminase as bio-catalyst. The catalyzed reaction exhibited high efficiency, selectivity, environmental friendliness. Collagen peptide grafted carboxymethylated chitosan was characterized by Fourier transform infrared spectroscopy. The process conditions were optimized including the reaction time, the reaction temperature, the molar ratio of collagen peptide to carboxymethylated chitosan and the pH value. The different molecular weight, concentration and degree of substitution of collagen peptide-carboxymethylated chitosan had crucial effects on the hydrogen peroxide scavenging activity of collagen peptide-carboxymethylated chitosan. The methyl thiazolyl tetrazolium assay showed that at a suitable concentration collagen peptide-carboxymethylated chitosan with different degree of substitution value could promote L929 mouse fibroblasts effectively. Therefore, the results suggest that collagen peptide-carboxymethylated chitosan could be potential wound dressings for clinical applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reactive and Functional Polymers - Volume 76, March 2014, Pages 26-31
نویسندگان
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