کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5275014 1385523 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydroethidine as a probe for measuring superoxide formation rates during air oxidation of myricetin and quercetin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Hydroethidine as a probe for measuring superoxide formation rates during air oxidation of myricetin and quercetin
چکیده انگلیسی

In the presence of the flavonols myricetin and quercetin, oxidation of hydroethidine (HE) by superoxide yielded ethidium (E+) instead of 2-hydroxyethidium (2-OH-E+). As a known pro-oxidant, myricetin alone was also found to be able to catalyze air oxidation of HE yielding exclusively E+. The reaction is inhibited by added superoxide dismutase, suggesting that superoxide is involved in the rate limiting step of the oxidation.

In the presence of the flavonols myricetin and quercetin, oxidation of hydroethidine (HE) by superoxide yielded ethidium (E+) instead of 2-hydroxyethidium (2-OH-E+). As a known pro-oxidant, myricetin alone was also found to be able to catalyze oxidation of HE to E+. The superoxide formation rates were quantified from the oxidation kinetics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 52, Issue 41, 12 October 2011, Pages 5384-5387
نویسندگان
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