کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5275014 | 1385523 | 2011 | 4 صفحه PDF | دانلود رایگان |

In the presence of the flavonols myricetin and quercetin, oxidation of hydroethidine (HE) by superoxide yielded ethidium (E+) instead of 2-hydroxyethidium (2-OH-E+). As a known pro-oxidant, myricetin alone was also found to be able to catalyze air oxidation of HE yielding exclusively E+. The reaction is inhibited by added superoxide dismutase, suggesting that superoxide is involved in the rate limiting step of the oxidation.
In the presence of the flavonols myricetin and quercetin, oxidation of hydroethidine (HE) by superoxide yielded ethidium (E+) instead of 2-hydroxyethidium (2-OH-E+). As a known pro-oxidant, myricetin alone was also found to be able to catalyze oxidation of HE to E+. The superoxide formation rates were quantified from the oxidation kinetics.
Journal: Tetrahedron Letters - Volume 52, Issue 41, 12 October 2011, Pages 5384-5387