کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5276474 1385558 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure and dynamics of pyrimidine-based macrocycles in solution
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure and dynamics of pyrimidine-based macrocycles in solution
چکیده انگلیسی

The conformational structure of macrocycles obtained from two thiopyrimidine and uracil nucleic acids linked by polymethylene spacers is determined by the length of the spacers, intramolecular NH bonding, pH and solvent. In CDCl3, NH-OC hydrogen bonding can impact the overall stabilization of the folded conformation, however spatial preorganization to such hydrogen bonding is a prerequisite. Protonation leads to disruption of intramolecular hydrogen bonds, destabilization of the folded conformation and to strong counterion assisted self-aggregation of macrocyles which can be destroyed in polar solvents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tetrahedron Letters - Volume 49, Issue 47, 17 November 2008, Pages 6674-6678
نویسندگان
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