Activity of palladium on charcoal catalysts in cross-coupling reactions

Comparison of the activity of several commercially available Pd/C catalysts in C-C, C-N, and C-S bond forming cross-coupling reactions has demonstrated the importance of the choice of the catalyst source. Investigations showed marked difference in activity between the catalysts. Moreover, the catalytic activity of each catalyst varies with respect to the coupling. The first Pd/C catalyzed Hiyama coupling is reported.