کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5370739 1503905 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular medicine - To be or not to be
ترجمه فارسی عنوان
داروهای مولکولی - آیا می شود یا نمی شود
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
چکیده انگلیسی


- A mutation of hemoglobin inducing Sickle cell anemia is the first molecular disease.
- The atomic structure of proteins opened new perspectives in molecular medicine.
- Protein misfolding is a critical event triggering neurodegenerative diseases.
- The Retromer is involved in the molecular mechanism of several neurological disorders.

Molecular medicine is founded on the synergy between Chemistry, Physics, Biology and Medicine, with the ambitious goal of tackling diseases from a molecular perspective. This Review aims at retracing a personal outlook of the birth and development of molecular medicine, as well as at highlighting some of the most urgent challenges linked to aging and represented by incurable neurodegenerative diseases caused by protein misfolding. Furthermore, we emphasize the emerging role of the retromer dysfunctions and improper protein sorting in Alzheimer's disease and other important neurological disordered.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biophysical Chemistry - Volumes 214–215, July–August 2016, Pages 33-46
نویسندگان
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