کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
541150 | 1450323 | 2016 | 5 صفحه PDF | دانلود رایگان |
• Fabrication of an active SERS substrate with arrays of silver nanoisland microholes
• A femtoliter hole volume reduces fluorescence emission and prevents signal absorption.
• Silver-decorated microholes allow analysis of non-transparent aqueous samples.
In this work we report on an active SERS (Surface Enhanced Raman Scattering) substrate with well-defined silver microholes for the investigation of liquid samples. The femtoliter volume confined in the holes allows to perform analysis of non-transparent aqueous solutions reducing fluorescence emission and avoiding signal absorption by surrounding liquid, which was demonstrated in the case of opaque and dye solutions. The micro-pattern based substrate was obtained by optical lithography and reactive ion etching and was selectively covered with silver nanoislands arranged in a highly homogeneous and isotropic way. Dopamine molecules and cell culture medium were used as probe analytes for SERS experiments showing that plasmonic microholes, having a very uniform enhancement, are suitable both for the detection of molecules with low Raman cross section and for the detection of biomolecules of non-transparent complex solutions. Finally, this kind of analysis requires only a tiny amount of analyte which is an important advancement for the measurements of costly or precious samples.
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Journal: Microelectronic Engineering - Volume 158, 1 June 2016, Pages 59–63