Solution thermodynamics of indomethacin in ethanol + propylene glycol mixtures

► Indomethacin solubility was maximal in neat ethanol and minimal neat propylene glycol. ► Thermodynamic quantities of solution and mixing were obtained for indomethacin. ► A non-linear plot of ∆solnH° vs. ∆solnG° compensation is found for indomethacin at 303.0 K.