Extended Hildebrand Solubility Approach applied to piroxicam in ethanol + water mixtures

► Piroxicam solubility at 298.15 K and some properties of drug fusion were determined. ► EHSA model was applied to evaluate the piroxicam behavior in ethanol + water mixtures at 298.15 K. ► A W vs. δ1 polynomial model in order five allows solubility estimation within an overall deviation of 2.41%.