کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5433784 1508996 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors
ترجمه فارسی عنوان
اتصال کلاسیک بلوک کوپلیمر-بور به خواص مؤثر بر جذب نوترون بورون تومورهای جامد
کلمات کلیدی
کنسانتره پلیمری دارویی، درمان نوترون بور، سیستم تحویل دارو، نفوذ تومور، بوروکاپیت سدیم،
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

Boron neutron capture therapy is a promising tumor treatment method, though its wide application has been limited due to the poor tumor selectivity and intracellular delivery of 10B-compounds. Here, block copolymer-boron cluster conjugate based on the clinically used sodium borocaptate (BSH) and poly(ethylene glycol)-b-poly(glutamic acid) copolymer have been developed for effectively penetrating tumor tissues and homogeneously delivering the boron clusters into cancer cells towards safe and efficient boron neutron capture therapy. The PEGylated block copolymer-boron cluster (BSH) conjugate has demonstrated significant higher cellular uptake and tumor accumulation when compared to the non-PEGylated formulations and BSH. Moreover, the enhanced delivery to tumors of the conjugates, as well as their superior intratumoral penetration, which facilitated reaching the intracellular space of most cells in tumors, allowed the effective ablation of tumors after neutron irradiation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 254, 28 May 2017, Pages 1-9
نویسندگان
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