کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5504548 | 1536762 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Macrophage C-type lectin is essential for phagosome maturation and acidification during Escherichia coli-induced peritonitis
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کلمات کلیدی
CRDBMDMsFcRγTDMPRRsCLRsMCLPhagosome acidificationLPSROS - ROSTLRs - TLR هاEscherichia coli - اشریشیا کُلیE. coli - باکتری E. coliphagosome maturation - بلوغ فوگوسومTrehalose dimycolate - تراهولوز دیمیوکولاتBacterial killing - قتل باکتریاییlipopolysaccharide - لیپوپلی ساکاریدMacrophage - ماکروفاژ Bone marrow-derived macrophages - ماکروفاژها حاصل از استخوان مغز استخوانReactive oxygen species - گونههای فعال اکسیژنpattern recognition receptors - گیرنده های تشخیص الگوC-type lectin receptors - گیرنده های لکتین نوع CToll-like receptors - گیرنده های پولی مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Sepsis is a life-threatening condition caused by an uncontrolled response to bacterial infection. Impaired bactericidal activity in the host is directly associated with severe sepsis; however, the underlying regulatory mechanism(s) is largely unknown. Here, we show that MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficient mice with E. coli-induced sepsis showed lower survival rates and reduced bacterial clearance when compared with control mice, despite similar levels of proinflammatory cytokine production. Although the ability of macrophages from MCL-deficient mice to kill bacteria was impaired, they showed normal phagocytic activity and production of reactive oxygen species. In addition, MCL-deficient macrophages showed defective phagosome maturation and phagosomal acidification after E. coli infection. Taken together, these results indicate that MCL plays an important role in host defense against E. coli infection by promoting phagosome maturation and acidification, thereby providing new insight into the role of MCL during pathogenesis of sepsis and offering new therapeutic options.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 493, Issue 4, 2 December 2017, Pages 1491-1497
Journal: Biochemical and Biophysical Research Communications - Volume 493, Issue 4, 2 December 2017, Pages 1491-1497
نویسندگان
Wook-Bin Lee, Ji-Jing Yan, Ji-Seon Kang, Lark Kyun Kim, Young-Joon Kim,