کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5504580 1400249 2017 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to nano-size titanium dioxide causes oxidative damages in human mesothelial cells: The crystal form rather than size of particle contributes to cytotoxicity
ترجمه فارسی عنوان
قرار گرفتن در معرض نیتروژن دی اکسید تیتانیوم سبب آسیب اکسیداتیو در سلول های مزوتلیال انسان می شود: شکل کریستال به جای اندازه ذرات باعث سمیت سلولی می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی
In this study, we focused on the morphology as well as the size of titanium dioxide particles. In comparing the effects between nano-size anatase and rutile titanium dioxide on human-derived pleural mesothelial cells, the anatase form was shown to be actively absorbed into cells, producing reactive oxygen species and causing oxidative damage to DNA. In contrast, we showed for the first time that the rutile form is not easily absorbed by cells and, therefore, does not cause oxidative DNA damage and is significantly less damaging to cells. These results suggest that with respect to the toxicity of titanium dioxide particles on human-derived mesothelial cells, the crystal form rather than the particle size has a greater effect on cellular absorption. Also, it was indicated that the difference in absorption is the primary cause of the difference in the toxicity against mesothelial cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 492, Issue 2, 14 October 2017, Pages 218-223
نویسندگان
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