کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5507782 | 1400349 | 2017 | 79 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DREF plays multiple roles during Drosophila development
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کلمات کلیدی
NURFDREFPNRYorkieSu(Hw)CP190ATRXPTZBSKSOPPLAmiRNAsTORHpo - HPORNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهProximity ligation assay - آزمون لمس نزدیکیhippo - اسب آبیchromatin immunoprecipitation - ایمن سازی کروماتینChromatin remodeling - بازسازی کروماتینTelomere - تلومرTranscription - رونویسیmicroRNAs - ریز آرانایBasket - سبدTumor suppressor - سرکوبگر تومورInsulator - عایقSignal transduction - هدایت سیگنالsensory organ precursor - پیش ساز ارگانیکCHiP - چیپYki - یکی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
DREF was originally identified as a transcription factor that coordinately regulates the expression of DNA replication- and proliferation-related genes in Drosophila. Subsequent studies demonstrated that DREF is involved in tumor suppressor pathways including p53 and Hippo signaling. DREF also regulates the expression of genes encoding components of the JNK and EGFR pathways during Drosophila development. DREF itself is under the control of the TOR pathway during cell and tissue growth responding to nutrition. Recent studies revealed that DREF plays a role in chromatin organization including insulator function, chromatin remodeling, and telomere maintenance. DREF is also involved in the regulation of genes related to mitochondrial biogenesis, linking it to cellular proliferation. Thus, DREF is now emerging as not only a transcription factor, but also a multi-functional protein. In this review, we summarize current advances in studies on the novel functions of Drosophila DREF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1860, Issue 6, June 2017, Pages 705-712
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1860, Issue 6, June 2017, Pages 705-712
نویسندگان
Nguyen Trong Tue, Yasuhide Yoshioka, Megumi Mizoguchi, Hideki Yoshida, Mario Zurita, Masamitsu Yamaguchi,