کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5508483 | 1537694 | 2017 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo
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کلمات کلیدی
PPARγ coactivator-1αTbx1LPLFGF21T2D[18F]-fluorodeoxyglucoseFDGPRDM16BATMicroPETGAPDHFASTMEM26LANCL2ABATGs - TG هاUcp1 - UCP1abscisic acid - اسید آبسزیکfatty acid synthase - اسید چرب سنتازinsulin - انسولینWAT, White adipose tissue - بافت چربی سفید، بافت ادیپوز سفیدbrown adipose tissue - بافت چربی قهوه ایTriglycerides - تریگلیسریدUncoupling protein-1 - جدا کردن پروتئین-1Type 2 diabetes - دیابت نوع 2fibroblast growth factor 21 - فاکتور رشد فیبروبلاست 21Lipoprotein lipase - لیپو پروتئین لیپازtransmembrane protein 26 - پروتئین غشایی 26WAT - چیGlycemic control - کنترل قند خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Silencing of LANCL2 abrogated both the ABA- and insulin-induced increase of glucose transporter-4 expression and of glucose uptake in differentiated 3T3-L1 murine adipocytes; conversely, overexpression of LANCL2 enhanced basal, ABA- and insulin-stimulated glucose uptake. As compared with insulin, ABA treatment of adipocytes induced lower triglyceride accumulation, CO2 production and glucose-derived fatty acid synthesis. ABA per se did not induce pre-adipocyte differentiation in vitro, but stimulated adipocyte remodeling in terminally differentiated cells, with a reduction in cell size, increased mitochondrial content, enhanced O2 consumption, increased transcription of adiponectin and of brown adipose tissue (BAT) genes. A single dose of oral ABA (1 μg/kg body weight) increased BAT glucose uptake 2-fold in treated rats compared with untreated controls. One-month-long ABA treatment at the same daily dose significantly upregulated expression of BAT markers in the WAT and in WAT-derived preadipocytes from treated mice compared with untreated controls. These results indicate a hitherto unknown role of LANCL2 in adipocyte sensitivity to insulin-stimulated glucose uptake and suggest a role for ABA in the induction and maintenance of BAT activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1862, Issue 2, February 2017, Pages 131-144
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1862, Issue 2, February 2017, Pages 131-144
نویسندگان
Laura Sturla, Elena Mannino, Sonia Scarfì, Santina Bruzzone, Mirko Magnone, Giovanna Sociali, Valeria Booz, Lucrezia Guida, Tiziana Vigliarolo, Chiara Fresia, Laura Emionite, Ambra Buschiazzo, Cecilia Marini, Gianmario Sambuceti, Antonio De Flora,