کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5527081 1401563 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammatory responses of stromal fibroblasts to inflammatory epithelial cells are involved in the pathogenesis of bovine mastitis
ترجمه فارسی عنوان
پاسخ های التهابی فیبروبلاست های استرومال به سلول های اپیتلیال التهابی در پاتوژنز ماستیت گاو دخیل هستند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


- Inflammatory BMEs affect the properties of BMFs during mastitis.
- BMEs inhibited the proliferation and promoted the migration of BMFs.
- BMEs enhanced secretion of inflammatory mediators and deposition of ECM in BMFs.
- Changes of the properties of BMFs were mediated by specific signal molecules.

Hypernomic secretion of epithelial cytokines has several effects on stromal cells. The contributions of inflammatory epithelial cells to stromal fibroblasts in bovine mammary glands with mastitis remain poorly understood. Here, we established an inflammatory epithelial cell model of bovine mastitis with gram-negative lipopolysaccharide (LPS) and gram-positive lipoteichoic acid (LTA) bacterial cell wall components. We characterized immune responses of mammary stromal fibroblasts induced by inflammatory epithelial cells. Our results showed that inflammatory epithelial cells affected stromal fibroblast characteristics by increasing inflammatory mediator expression, elevating extracellular matrix protein deposition, decreasing proliferation capacity, and enhancing migration ability. The changes in stromal fibroblast proliferation and migration abilities were mediated by signal molecules, such as WNT signal pathway components. LPS- and LTA-induced inflammatory epithelial cells triggered different immune responses in stromal fibroblasts. Thus, in mastitis, bovine mammary gland stromal fibroblasts were affected by inflammatory epithelial cells and displayed inflammation-specific changes, suggesting that fibroblasts play crucial roles in bovine mastitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 349, Issue 1, 15 November 2016, Pages 45-52
نویسندگان
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