کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5536489 1402291 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunogenicity of mumps virus vaccine candidates matching circulating genotypes in the United States and China
ترجمه فارسی عنوان
ایمنی زایی از کاندیدای واکسن ویروس اپیدورال با ژنوتیپ های موجود در ایالات متحده و چین
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
Mumps virus (MuV) causes acute infection in humans with characteristic swelling of the parotid gland. While vaccination has greatly reduced the incidence of MuV infection, there have been multiple large outbreaks of mumps virus (MuV) in highly vaccinated populations. The most common vaccine strain, Jeryl Lynn, belongs to genotype A, which is no longer a circulating genotype. We have developed two vaccine candidates that match the circulating genotypes in the United States (genotype G) and China (genotype F). We found that there was a significant decrease in the ability of the Jeryl Lynn vaccine to produce neutralizing antibody responses to non-matched viruses, when compared to either of our vaccine candidates. Our data suggests that an updated vaccine may allow for better immunity against the circulating MuV genotypes G and F.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 35, Issue 32, 13 July 2017, Pages 3988-3994
نویسندگان
, , , , ,