کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5546468 1402744 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An insight into the sialome of Hyalomma excavatum
ترجمه فارسی عنوان
نگاهی به سیلوم هیالومما اککتوماتوم
کلمات کلیدی
تیک، غدد بزاقی، بزاق، ترانسکتیکوم سیلوموم
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی
Tick saliva contains hundreds or thousands of proteins that help blood feeding by impairing their hosts' hemostasis, inflammation and immunity. Salivary gland transcriptomes allow the disclosure of this pharmacologically active potion that consists of several multi-gene families, many of which are tick-specific. We here report the “de novo” assembly of ∼138 million reads deriving from a cDNA library from salivary glands of adult male and female Hyalomma excavatum leading to the public deposition of 5337 coding sequences to GenBank. Among the deducted putative secreted proteins, metalloproteases, glycine rich proteins, mucins, anticoagulants of the madanin family and lipocalins were the most expressed. Novel protein families were identified. These sequences will permit proteomic studies aiming at identification of target antigens, epidemiological markers or salivary pharmaceuticals of interest, and contribute to our understanding of the fast evolution of the tick sialome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ticks and Tick-borne Diseases - Volume 8, Issue 2, February 2017, Pages 201-207
نویسندگان
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