کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5549574 1556737 2016 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extrusion-spheronization a promising pelletization technique: In-depth review
ترجمه فارسی عنوان
اکستروژن-اسفرئین سازی یک روش دانه سازی امیدوار کننده: بررسی عمیق
کلمات کلیدی
گلوله تکنیک های ذرت، اکستروژن-اسفنجی، پارامترهای کیفیت، خصوصیات پلت،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

This review article deals with various aspects of the extrusion-spheronization technique. The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation (moisture content, granulating liquid, excipients, and drugs), equipment (mixer, extruder, friction plate, and extrusion screen) and process (extrusion speed, extrusion temperature, spheronizer load, spheronization time, spheronization speed, and drying method) are discussed. In the final part, methods available for characterization (particle size distribution, surface area, shape and sphericity, porosity, density, hardness and friability, flow properties, disintegration, and dissolution) of the pellets are explained.

Graphical AbstractFirst, different steps such as granulation, extrusion, spheronization and drying of the extrusion-spheronization process are mentioned. Then the parameters that can influence the pellet quality which involves formulation, equipment and process parameters are discussed. Finally, methods available for characterization of the pellets are explained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 11, Issue 6, December 2016, Pages 684-699
نویسندگان
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