کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550006 1557282 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanistic modeling of a capsule filling process
ترجمه فارسی عنوان
مدل سازی مکانیکی فرایند پر کردن کپسول
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Filling a dosator nozzle moving into a powder bed was investigated using the Discrete Element Method (DEM). Various particle diameters and contact properties were modeled. The simulations qualitatively showed the influence of powder properties on the amount of dosed powder. Two factors that influence the dosed mass were observed. First, the ratio between the particle and dosator diameters affects the packing of particles inside the dosator chamber. Second, the flow behavior of the powder significantly modifies its filling and compression behavior. Cohesive powders pack less densely inside the powder bed, which could lead to a lower amount of dosed powder. In contrast, cohesive powders are compressed more during dosing and the density inside the dosator chamber increases during the dosing process. Since the simulation of fine cohesive powders is numerically impossible due to a high number of particles and small simulation time steps, we applied a simple method for particle scaling to acquire a qualitative understanding of the filling behavior of coarse and fine powders.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 532, Issue 1, 30 October 2017, Pages 47-54
نویسندگان
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