کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550047 1557282 2017 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymeric micelles: Basic research to clinical practice
ترجمه فارسی عنوان
میسلیوم پلیمر: تحقیقات پایه ای به عمل بالینی
کلمات کلیدی
میسلی آمفیفیلیس، میسلیل پلیمری، تحویل مواد مخدر، بلوک کوپلیمر، کاربرد بالینی، هدفگیری مواد مخدر،
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Rapidly developing polymeric micelles as potential targeting carriers has intensified the need for better understanding of the underlying principles related to the selection of suitable delivery materials for designing, characterizing, drug loading, improving stability, targetability, biosafety and efficacy. The emergence of advanced analytical tools such as fluorescence resonance energy transfer and dissipative particle dynamics has identified new dimensions of these nanostructures and their behavior in much greater details. This review summarizes recent efforts in the development of polymeric micelles with respect to their architecture, formulation strategy and targeting possibilities along with their preclinical and clinical aspects. Literature of the past decade is discussed critically with special reference to the chemistry involved in the formation and clinical applications of these versatile materials. Thus, our main objective is to provide a timely update on the current status of polymeric micelles highlighting their applications and the important parameters that have led to successful delivery of drugs to the site of action.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 532, Issue 1, 30 October 2017, Pages 249-268
نویسندگان
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