کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550678 1557298 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methods to simulate rubbing of topical formulation for in vitro skin permeation studies
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Methods to simulate rubbing of topical formulation for in vitro skin permeation studies
چکیده انگلیسی

Rubbing a topical formulation on skin is generally assumed to enhance drug penetration. The aim of this study was to demonstrate different techniques such as using glass rod, rheometer, and gloved finger for rubbing a 2% salicylic acid gel on skin and investigate their effect on in vitro permeation of salicylic acid through dermatomed porcine ear skin. The studies included evaluation of the gel's rheological properties, gel distribution on skin surface, in vitro permeability, drug distribution in skin, skin extraction recovery, and mass balance. Rubbing with a gloved finger resulted in a uniform gel layer with a thickness of 49.61 ± 15.33 μm on the skin surface. No significant difference between the different test groups was observed in terms of the cumulative amount of drug that permeated in 24 h (p > 0.05). Drug levels in stratum corneum, epidermis, and dermis were also analyzed. Rubbing with gloved finger delivered significantly higher amount of drug into the skin layers as compared to other test groups (p < 0.05). Amount of drug extracted from skin was reliably correlated to the actual drug levels in skin (R2 = 0.99). Considering drug amounts in different compartments, mass balance ranged from 75.86 ± 2.90% to 80.44 ± 2.99%.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 519, Issues 1–2, 15 March 2017, Pages 22-33
نویسندگان
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