کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5550756 1557300 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer's disease
ترجمه فارسی عنوان
اثر تجویز خوراکی کورستین نانو کپسوله شده بر روی یک مدل موش با بیماری آلزایمر
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

Quercetin has been identified as a promising compound with a neuroprotective potential against age-related neurodegenerative diseases such as Alzheimer's disease (AD). Nevertheless, the clinical application of quercetin is hampered by its low oral bioavailability. The aim of this work was to evaluate the capability of nanoencapsulated quercetin in zein nanoparticles (NPQ), that significantly improves the oral absorption and bioavailability of the flavonoid, as potential oral treatment for AD. For this purpose, SAMP8 mice were orally treated for two months with either NPQ (25 mg/kg every 48 h) or a solution of quercetin (Q; 25 mg/kg daily). NPQ displayed a size of 260 nm and a payload of about 70 μg/mg. For Q, no significant effects were observed in animals. On the contrary, the oral administration of NPQ improved the cognition and memory impairments characteristics of SAMP8 mice. These observations appeared to be related with a decreased expression of the hippocampal astrocyte marker GFAP. Furthermore, significant levels of quercetin were quantified in the brain of mice treated with nanoparticles. These findings highlight the potential of zein nanoparticles to promote the oral absorption of quercetin as well as the therapeutic potential of this flavonoid in AD pathogenesis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 517, Issues 1–2, 30 January 2017, Pages 50-57
نویسندگان
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