کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5551444 | 1557758 | 2017 | 6 صفحه PDF | دانلود رایگان |
- Nonwoven nano fibers of cellulose acetate phthalate were developed successfully.
- The fibers were loaded with curcumin and its in vitro transdermal release property was studied.
- The as-prepared fibers demonstrated controlled in vitro transdermal delivery of CUR for up to 24Â h.
Novel curcumin (CUR)-loaded cellulose acetate phthalate (CAP) nonwoven electrospun nanofiber (NF) transdermal mat was developed and evaluated for its in vitro CUR diffusion properties. Various CAP solutions from 5 to 20Â wt% were tested; 17.5Â wt% was found to be a suitable concentration for NF fabrication without defects, such as bubble or ribbon structures. The selected wt% CAP solution was loaded with CUR and electrospun into NFs. The prepared CUR-loaded NFs were characterized using scanning electron microscopy, X-ray diffraction, ultraviolet-visible spectroscopy, thermogravimetric analysis (TGA), and in vitro diffusion studies. The as-prepared fibers demonstrated controlled in vitro transdermal delivery of CUR for up to 24Â h.
Journal: Saudi Pharmaceutical Journal - Volume 25, Issue 6, September 2017, Pages 921-926