کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5557543 | 1560826 | 2017 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Therapeutic potential of hepcidin â the master regulator of iron metabolism Therapeutic potential of hepcidin â the master regulator of iron metabolism](/preview/png/5557543.png)
Iron is an essential biogenic element for both prokaryotic and eukaryotic cells. In humans iron is present in hundreds of different metalloproteins. The peptide hormone hepcidin serves as a master regulator of iron homeostasis on the level of single cells and whole organism â by altering cell surface expression of cellular iron exporter â protein ferroportin. Altered levels of extracellular hepcidin lead to pathological conditions such as hemochromatosis and iron loading or, on the other side, iron restrictive anemias. Therapeutic modulation of hepcidin is a new and promising approach to treatment of these conditions. In this review, a summary of the current knowledge of hepcidin function, regulation and pathological involvements are provided, followed by a section covering the therapeutic potential of hepcidin and the current strategies how to modulate its levels and biological functions for therapeutic purposes.
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Journal: Pharmacological Research - Volume 115, January 2017, Pages 242-254