کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5558074 1403197 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors
ترجمه فارسی عنوان
نقش میکروگلای در سکته مغزی و بهبودی ایسکمیک: تمرکز بر گیرنده های پولی مانند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


- Post-ischemic microglial responses are divided to acute, subacute and long-term phases.
- Inflammatory response has major role in the pathophysiology of ischemic stroke.
- TLRs are a receptor family mediating innate immunity.
- More studies focusing on the long-term microglial activation after stroke are needed.

Stroke is the leading cause of disability in adults. Drug treatments that target stroke-induced pathological mechanisms and promote recovery are desperately needed. In the brain, an ischemic event triggers major inflammatory responses that are mediated by the resident microglial cells. In this review, we focus on the microglia activation after ischemic brain injury as a target of immunomodulatory therapeutics. We divide the microglia-mediated events following ischemic stroke into three categories: acute, subacute, and long-term events. This division encompasses the spatial and temporal dynamics of microglia as they participate in the pathophysiological changes that contribute to the symptoms and sequela of a stroke. The importance of Toll-like receptor (TLR) signaling in the outcomes of these pathophysiological changes is highlighted. Increasing evidence shows that microglia have a complex role in stroke pathophysiology, and they mediate both detrimental and beneficial effects on stroke outcome. So far, most of the pharmacological studies in experimental models of stroke have focused on neuroprotective strategies which are impractical for clinical applications. Post-ischemic inflammation is long lasting and thus, could provide a therapeutic target for novel delayed drug treatment. However, more studies are needed to elucidate the role of microglia in the recovery process from an ischemic stroke and to evaluate the therapeutic potential of modulating post-ischemic inflammation to promote functional recovery.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 79, Part A, 3 October 2017, Pages 3-14
نویسندگان
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