کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5558570 | 1561143 | 2017 | 10 صفحه PDF | دانلود رایگان |

- Single oral administration of MEAI (10Â mg/kg) to rats was well tolerated.
- Five-day oral administration of MEAI (30Â mg/kg) to rats was well tolerated.
- Low cytotoxicity was observed in the in vitro cytotoxicity assays.
- Ethanol-MEAI mixtures induced no synergistic/additive neurotoxicity.
5-Methoxy-2-aminoindane (MEAI) is a psychoactive compound of the aminoindane class, which in recent years has been recreationally used by many people, who reported of a mild euphoric, alcohol-like tipsy experience and reduced desire to consume alcoholic beverages. In the light of these observations it was decided to progress MEAI through a preliminary drug development route and evaluate the acute and subacute toxicity of MEAI administrated orally to Sprague Dawley rats, as well as to determine potential in-vitro cytotoxic and mutagenic effects using state-of-the-art protocols. Furthermore, the interaction of MEAI at the highest non-toxic concentration (100Â mg/L) with ethanol at cytotoxic levels of 6% and 7.5% was explored, in order to identify possible additive or synergistic effects.MEAI showed a good safety profile in rats at 10 and 30Â mg/kg body weight, corresponding to the human doses of 1.6Â mg/kg and 4.8Â mg/kg body weight, respectively. Cytotoxic effect was demonstrated using concentrations of 500 and 1000Â mg/L with calculated IC50 value of 368.2Â mg/L for rat brain striatum primary neurons and 403.1Â mg/L for human primary healthy hepatocytes. The combination of 6% or 7.5% ethanol with 100Â mg/L MEAI revealed no statistically significant increase of cytotoxic effect. Further studies, especially long term chronic and addictive behavior studies, are required in-order to assess MEAI safety profile.
Journal: Toxicology and Applied Pharmacology - Volume 319, 15 March 2017, Pages 59-68