کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560354 | 1403316 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment
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کلمات کلیدی
GnRHintersegmental vesselsPRLIPAppbhpfEDCs - EDC هاUS EPA - EPA ایالات متحدهatrazine - آترازینUnited States Environmental Protection Agency - آژانس حفاظت از محیط زیست ایالات متحدهIngenuity Pathway Analysis - تجزیه و تحلیل راه Ingenuityanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceCNS - دستگاه عصبی مرکزیDevelopment - رشدhours post fertilization - ساعت پس از لقاحcentral nervous system - سیستم عصبی مرکزیparts per billion - قطعات در هر میلیاردTranscriptomics - متن ترانهEndocrine Disrupting Chemicals - مواد شیمیایی خرابکار غدد درون ریزMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAgonadotropin releasing hormone - هورمون آزاد کننده گنادوتروپینfollicle stimulating hormone - هورمون تحریک کننده فولیکولFSH - هورمون محرکه فولیکولی Prolactin - پرولاکتین Zebrafish - گورخرماهی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
MicroRNAs (miRNAs) are short, single-stranded RNA that regulate post-transcriptional control of mRNA translation. Knowledge on the role of these critical regulators in toxicological responses in increasing, but is still limited. Atrazine is a herbicide used throughout the Midwestern US that is reported to frequently contaminate potable water supplies above the maximum contaminant level of 3Â parts per billion. Atrazine is a suspected endocrine disrupting chemical and studies have begun to investigate the genetic mechanisms of toxicity; however, studies investigating epigenetic mechanisms are limited. In this study both zebrafish and human miRNAs were significantly altered in response to an embryonic atrazine exposure of 0.3, 3, or 30Â ppb in zebrafish. Altered miRNAs are known to play a role in angiogenesis, cancer, or neuronal development, differentiation, and maturation. Targeted analysis of altered human miRNAs with genes previously identified to be altered by atrazine exposure revealed several targets linked to cell cycle and cell signaling. Further analysis of hsa-miRNA-126-3p, which had altered expression in all three atrazine treatments at 72Â hpf, revealed alterations also occurred at 60Â hpf in the 30Â ppb treatment group. Results from this study indicate miRNA deregulation in zebrafish and human miRNAs following an embryonic atrazine exposure in zebrafish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 98, Part A, December 2016, Pages 25-33
Journal: Food and Chemical Toxicology - Volume 98, Part A, December 2016, Pages 25-33
نویسندگان
Sara E. Wirbisky, Gregory J. Weber, Kelly E. Schlotman, Maria S. Sepúlveda, Jennifer L. Freeman,