کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561168 | 1562115 | 2017 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A 12-week randomized clinical trial investigating the potential for sucralose to affect glucose homeostasis
ترجمه فارسی عنوان
یک کارآزمایی بالینی تصادفی 12 هفته ای که امکان بالارفتن سوکرالوز را برای تأثیر بر هورمون های گلوکز را بررسی می کند
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کلمات کلیدی
GLP-1SGLT1HbA1cOGTTNNSGIPEFSAGLUT2AUC - AUCOral glucose tolerance test - آزمون تحمل گلوکز خوراکیEuropean Food Safety Authority - اداره ایمنی اروپاHealthy volunteers - داوطلبان سالمWorld Health Organization - سازمان بهداشت جهانیSucralose - ساکرالوزarea under the curve - منطقه تحت منحنیGlycated hemoglobin - هموگلوبین گلیکوزیلهGlucose homeostasis - هوموستاز گلوکزglucagon-like peptide 1 - پپتید مشابه گلوکاگون 1Gastric inhibitory peptide - پپتید مهار کننده معدهWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The discovery of gut sweet taste receptors has led to speculations that non-nutritive sweeteners, including sucralose, may affect glucose control. A double-blind, parallel, randomized clinical trial, reported here and previously submitted to regulatory agencies, helps to clarify the role of sucralose in this regard. This was primarily an out-patient study, with 4-week screening, 12-week test, and 4-week follow-up phases. Normoglycemic male volunteers (47) consumed â¼333.3Â mg encapsulated sucralose or placebo 3x/day at mealtimes. HbA1c, fasting glucose, insulin, and C-peptide were measured weekly. OGTTs were conducted in-clinic overnight, following overnight fasting twice during screening phase, twice during test phase, and once at follow-up. Throughout the study, glucose, insulin, C-peptide and HbA1c levels were within normal range. No statistically significant differences between sucralose and placebo groups in change from baseline for fasting glucose, insulin, C-peptide and HbA1c, no clinically meaningful differences in time to peak levels or return towards basal levels in OGTTs, and no treatment group differences in mean glucose, insulin, or C-peptide AUC change from baseline were observed. The results of other relevant clinical trials and studies of gastrointestinal sweet taste receptors are compared to these findings. The collective evidence supports that sucralose has no effect on glycemic control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 88, August 2017, Pages 22-33
Journal: Regulatory Toxicology and Pharmacology - Volume 88, August 2017, Pages 22-33
نویسندگان
V. Lee Grotz, Xavier Pi-Sunyer, Daniel Jr., Ashley Roberts, J. Richard Trout,