کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561380 | 1562118 | 2017 | 12 صفحه PDF | دانلود رایگان |
- The LD50 of vanadyl trehalose was established at 1000Â mg/kg BW of the tested Kunming (KM) mice.
- The mainly toxic target organs of vanadyl trehalose were stomach and intestine.
- Vanadyl trehalose also showed a mild genotoxicity.
A new trend has been developed using vanadium and organic ligands to form novel compounds in order to improve the beneficial actions and reduce the toxicity of vanadium compounds. In present study, vanadyl trehalose was explored the oral acute toxicity, 28 days repeated dose toxicity and genotoxicity in Kunming mice. The Median Lethal Dose (LD50) of vanadyl trehalose was revealed to be 1000Â mg/kg body weight in fasted Kunming mice. Stomach and intestine were demonstrated to be the main target organs of vanadyl trehalose through 28 days repeated dose toxicity study. And vanadyl trehalose also showed particular genotoxicity through mouse bone marrow micronucleus and mouse sperm malformation assay. In brief, vanadyl trehalose presented certain, but finite toxicity, which may provide experimental basis for the clinical application.
Journal: Regulatory Toxicology and Pharmacology - Volume 85, April 2017, Pages 86-97