کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5561380 1562118 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute toxicity, twenty-eight days repeated dose toxicity and genotoxicity of vanadyl trehalose in kunming mice
ترجمه فارسی عنوان
سمیت حاد، بیست و هشت روز سمیت مکرر دوز و سمیت نسبی وانادیل تر هالوز در موش های کونمینگ
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- The LD50 of vanadyl trehalose was established at 1000 mg/kg BW of the tested Kunming (KM) mice.
- The mainly toxic target organs of vanadyl trehalose were stomach and intestine.
- Vanadyl trehalose also showed a mild genotoxicity.

A new trend has been developed using vanadium and organic ligands to form novel compounds in order to improve the beneficial actions and reduce the toxicity of vanadium compounds. In present study, vanadyl trehalose was explored the oral acute toxicity, 28 days repeated dose toxicity and genotoxicity in Kunming mice. The Median Lethal Dose (LD50) of vanadyl trehalose was revealed to be 1000 mg/kg body weight in fasted Kunming mice. Stomach and intestine were demonstrated to be the main target organs of vanadyl trehalose through 28 days repeated dose toxicity study. And vanadyl trehalose also showed particular genotoxicity through mouse bone marrow micronucleus and mouse sperm malformation assay. In brief, vanadyl trehalose presented certain, but finite toxicity, which may provide experimental basis for the clinical application.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 85, April 2017, Pages 86-97
نویسندگان
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