کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561675 | 1562152 | 2017 | 12 صفحه PDF | دانلود رایگان |
- Lifetime pesticide use was associated with reduced LH and prolactin levels.
- Lifetime use of pesticides was also associated with poorer sperm morphology.
- Maternal farming during pregnancy was associated with larger AGD and TV.
- Results support the hypothesis that pesticides may affect male reproductive system.
The association of occupational exposure to current-use pesticides with reproductive hormones, semen quality, and genital measures was investigated among young men in the South of Brazil. A cross-sectional study was conducted in 99 rural and 36 urban men aged 18-23 years. Information on pesticide use was obtained through questionnaire. Serum and semen samples were analyzed for sex hormones and sperm parameters, respectively, and measurement of anogenital distance (AGD) and testis volume (TV) were performed. Associations were explored using multivariate linear regression. Rural men had poorer sperm morphology, higher sperm count, and lower LH levels relative to urban subjects. Lifetime use of pesticides, especially herbicides and fungicides, was associated with poorer morphology and reduced LH and prolactin, with evidence of a linear pattern. Maternal farming during pregnancy was associated with larger AGD and TV. Chronic occupational exposure to modern pesticides may affect reproductive outcomes in young men.
Journal: Reproductive Toxicology - Volume 67, January 2017, Pages 174-185