کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5585940 | 1404397 | 2016 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish
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کلمات کلیدی
HSCDPFPH3CEBPαRBIWISH - آرزو کردنdays post fertilization - بارور شدن روزانهBrdU - بروموداکسی اوریدینbromodeoxyuridine - برومودسوویریدینNeutral red - خنثی قرمزDevelopment - رشدHematopoietic stem cell - سلول بنیادی هماتوپوئیتSudan Black B - سودان سیاه بWhole mount in situ hybridization - کل کوهنوردی در محلZebrafish - گورخرماهی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
In vertebrates, myeloid cells arise from multiple waves of development: the first or embryonic wave of myelopoiesis initiates early from non-hematopoietic stem cell (HSC) precursors and gives rise to myeloid cells transiently during early development; whereas the second or adult wave of myelopoiesis emerges later from HSCs and produces myeloid cells continually during fetal and adult life. In the past decades, a great deal has been learnt about the development of myeloid cells from adult myelopoiesis, yet the genetic network governing embryonic myelopoiesis remains poorly defined. In this report, we present an in vivo study to delineate the role of Cebpα during zebrafish embryonic myelopoiesis. We show that embryonic myelopoiesis in cebpα-deficient zebrafish mutants initiates properly but fails to produce macrophages and neutrophils. The lack of macrophages and neutrophils in the mutants is largely attributed to the cell cycle arrest of embryonic myeloid progenitors, resulting in the impairment of their maintenance and subsequent differentiation. We further show that Cebpα, perhaps acting cooperatively with Runx1, plays a critical role in embryonic neutrophil maintenance. Our findings reveal a new role of Cebpα in embryonic myelopoiesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Genetics and Genomics - Volume 43, Issue 10, 20 October 2016, Pages 593-600
Journal: Journal of Genetics and Genomics - Volume 43, Issue 10, 20 October 2016, Pages 593-600
نویسندگان
Yimei Dai, Lu Zhu, Zhibin Huang, Minyu Zhou, Wan Jin, Wei Liu, Mengchang Xu, Tao Yu, Yiyue Zhang, Zilong Wen, Wangjun Liao, Wenqing Zhang,