کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5588589 | 1569106 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA
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کلمات کلیدی
EPASBSArachidonic acid - اسید آراشیدونیکEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکLinoleic acid - اسید لینولئیکFatty acids - اسیدهای چربPiglet - بچه خوکParenteral nutrition - تغذیه تزریقیARA - در حال حاضرDHA - دوکوساهگزائنوئیک اسیدIntestinal adaptation - سازگاری رودهShort bowel syndrome - سندرم روده کوتاه، سندرم روده کوچکFat - چربی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Infants with short bowel syndrome (SBS) are at high risk for malabsorption, malnutrition, and failure to thrive. The objective of this study was to evaluate in a porcine model of SBS, the systemic absorption of a novel enteral Docosahexaenoic acid (DHA) formulation that forms micelles independent of bile salts (DHA-ALT®). We hypothesized that enteral delivery of DHA-ALT® would result in higher blood levels of DHA compared to a control DHA preparation due to improved intestinal absorption. SBS was induced in term piglets through a 75% mid-jejunoileal resection and the piglets randomized to either DHA-ALT® or control DHA formulation (N = 5 per group) for 4 postoperative days. The median ± IQR difference in final vs starting weight was 696 ± 425 g in the DHA-ALT® group compared to 132 ± 278 g in the controls (P = .08). Within 12 hours, median ± IQR DHA and eicosapentaenoic acid plasma levels (mol%) were significantly higher in the DHA-ALT® vs control group (4.1 ± 0.3 vs 2.5 ± 0.5, P = .009; 0.7 ± 0.3 vs 0.2 ± 0.005, P = .009, respectively). There were lower fecal losses of DHA and greater ileal tissue incorporation with DHA-ALT® vs the control. Morphometric analyses demonstrated an increase in proximal jejunum and distal ileum villus height in the DHA-ALT® group compared to controls (P = .01). In a neonatal porcine model of SBS, enteral administration of a novel DHA preparation that forms micelles independent of bile salts resulted in increased fatty acid absorption, increased ileal tissue incorporation, and increased systemic levels of DHA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 39, March 2017, Pages 51-60
Journal: Nutrition Research - Volume 39, March 2017, Pages 51-60
نویسندگان
Camilia R. Martin, Barbara Stoll, Joanne Cluette-Brown, Adesola C. Akinkuotu, Oluyinka O. Olutoye, Kathleen M. Gura, Pratibha Singh, Munir M. Zaman, Michael C. Perillo, Mark Puder, Steven D. Freedman, Doug Burrin,