کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5588624 1569105 2017 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased cytokine production by monocytes from human subjects who consumed grape powder was not mediated by differences in dietary intake patterns
ترجمه فارسی عنوان
افزایش تولید سیتوکین توسط مونوسیت ها از افراد انسانی که مصرف پودر انگور را با اختلاف در الگوهای مصرف غذا متاثر نکردند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Recently, in a randomized, double-blind crossover study, we reported that consumption of grape powder by obese human subjects increased the production of the proinflammatory cytokines interleukin (IL)-1β and IL-6 by peripheral blood monocytes after ex vivo stimulation with bacterial lipopolysaccharide compared with the placebo treatment. We hypothesized that dietary grape powder increased the production of these cytokines by stimulated monocytes. To test this hypothesis, we used 24-hour dietary recall data to determine if differences in dietary patterns played a role in increased cytokine production. No differences in total energy, protein, carbohydrates, or fat intake in the diets were observed between the grape powder and placebo intervention periods. There were no differences observed in consumption of meats and poultry, eggs, fish, vegetables, grains, total dairy, or nuts and seeds by the participants between the 2 intervention periods. When participants received the grape powder, the recall data showed decreased intakes of butyric and capric acids (P < .05), and a possible trend toward decreased intake of cheese and total fruit (P < .1). Positive associations between the intakes of margaric acid, butter, total dairy, or whole grain and IL-6 production were observed (P < .05). However, path analysis showed that total energy, protein, carbohydrates, and fats, and individual fatty acids did not influence the production of cytokines by monocytes. The path analysis indicated that the increased cytokine production by lipopolysaccharide-stimulated monocytes from obese human subjects was caused by the grape powder and not mediated by differences in dietary intake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 40, April 2017, Pages 32-39
نویسندگان
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