Comprehensive Left Atrial Appendage Optimization of Thrombus Using Surface Echocardiography: The CLOTS Multicenter Pilot Trial

The CLOTS multicenter pilot trial determined that TTE is useful in the detection of thrombus using harmonic imaging combined with intravenous contrast (Optison; GE Healthcare, Milwaukee, WI). Additionally, LAA wall DTI velocities on TTE are useful in determining the severity of LAA SEC and detecting sludge or thrombus.