Pseudonormal Mitral Filling Is Associated with Similarly Poor Prognosis as Restrictive Filling in Patients with Heart Failure and Coronary Heart Disease: A Systematic Review and Meta-analysis of Prospective Studies

This literature-based meta-analysis, pooling results from 7 prospective studies, demonstrates the 4-fold increase in odds of death associated with pseudonormal filling compared with abnormal relaxation/normal. The pseudonormal filling pattern and restrictive filling pattern are associated with similar risk of death. These data further support the need for a comprehensive assessment of diastolic filling, including assessment for pseudonormal filling, as part of routine echocardiographic risk stratification in patients with HF and CAD.