کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5622628 | 1406183 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease
ترجمه فارسی عنوان
عملکرد روزمره خودسنجی و اطلاعاتی نسبت به نشانگرهای هدفمند بیماری آلزایمر
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کلمات کلیدی
everyday functionMild cognitive impairment (MCI) - اختلال شناختی خفیف (MCI)Alzheimer's disease - بیماری آلزایمرDementia - جنون یا زوال عقلSelf-report - خودگزارشیDaily functioning - عملکرد روزانهInstrumental Activities of Daily Living - فعالیت های ابزار زندگی روزمرهBiomarkers - نشانگر زیستی یا بیومارکرADNI - کمک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self- and/or informant-rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [18F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 9, September 2015, Pages 1080-1089
Journal: Alzheimer's & Dementia - Volume 11, Issue 9, September 2015, Pages 1080-1089
نویسندگان
Alicia D. Rueda, Karen M. Lau, Naomi Saito, Danielle Harvey, Shannon L. Risacher, Paul S. Aisen, Ronald C. Petersen, Andrew J. Saykin, Sarah Tomaszewski Farias, Alzheimer's Disease Neuroimaging Initiative Alzheimer's Disease Neuroimaging Initiative,