کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622693 1406186 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleThe influence of cerebrospinal fluid (CSF) biomarkers on clinical dementia evaluations
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleThe influence of cerebrospinal fluid (CSF) biomarkers on clinical dementia evaluations
چکیده انگلیسی

BackgroundCerebrospinal fluid (CSF) proteins have become accepted biomarkers of Alzheimer's disease (AD) in research settings. The extent of their use, perceived utility, and influence on decision making in clinical settings, however, are less well studied.MethodsClinicians who evaluate older adults (N = 193) were randomized to view normal, borderline, AD-consistent, or no CSF information in two vignettes portraying patients with borderline and mild AD symptoms. Clinicians also reported on the use and perceived utility of CSF biomarkers.ResultsAlthough clinicians reported infrequent use and low perceived utility of CSF biomarkers, viewing AD-consistent CSF values made clinicians more likely to make an AD-related diagnosis, increased diagnostic confidence, and led clinicians to initiate treatment more often than clinicians who had no CSF information.ConclusionsCSF biomarkers influence decision making depending on the extent to which biomarkers reflect AD pathology, consistency between clinical-pathologic information, and the ambiguity of protein values.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 5, May 2015, Pages 533-540.e2
نویسندگان
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