کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622695 1406186 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review ArticleGuidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Review ArticleGuidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research
چکیده انگلیسی

The lack of readily available biomarkers is a significant hindrance toward progressing to effective therapeutic and preventative strategies for Alzheimer's disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field to foster cross-validation across cohorts and laboratories.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 5, May 2015, Pages 549-560
نویسندگان
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