کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622794 1406190 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleThe impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study
ترجمه فارسی عنوان
مقالات ویژه: تاثیر حجم سنجی اتوماتیک هیپوکامپ بر اعتماد تشخیصی در بیماران مبتلا به بیماری آلزایمر: یک مطالعه کنسرسیوم بیماری آلزایمر اروپا
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

IntroductionHippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear.MethodsThree hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination ≥20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed.ResultsAn increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of −8.0% (95% credible interval: [−11.5, −5.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (−8.5, CrI: [−11.5, −5.6]; −14.1, CrI: [−19.3, −8.8]; −10.6, CrI: [−14.6, −6.1], respectively).DiscussionThere is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 9, September 2017, Pages 1013-1023
نویسندگان
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