کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622838 1406192 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleBasal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects
ترجمه فارسی عنوان
آتروفی پیش داروی پیشگیری شده و تحریک آمیلوئید قشر در افراد مسن سالم
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

BackgroundBoth neurodegeneration of the cholinergic basal forebrain (BF) and deposition of β-amyloid are early events in the course of Alzheimer's disease (AD). Associations between increased amyloid pathology and cholinergic atrophy have been described in autopsy studies.MethodsWe used structural MRI and AV45-PET amyloid imaging data of 225 cognitively normal or mildly impaired elderly subjects from the Alzheimer's Disease Neuroimaging Initiative to assess in vivo associations between BF atrophy and cortical amyloid deposition. Associations were examined using region-of-interest (ROI) and voxel-based approaches with reference to cytoarchitectonic mappings of the cholinergic BF nuclei.ResultsROI- and voxel-based approaches yielded complementary evidence for an association between BF volume and cortical amyloid deposition in presymptomatic and predementia stages of AD, irrespective of age, gender, and APOE genotype.ConclusionsThe observed correlations between BF atrophy and cortical amyloid load likely reflect associations between cholinergic degeneration and amyloid pathology as reported in neuropathologic examination studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 10, Issue 5, Supplement, October 2014, Pages S344-S353
نویسندگان
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