کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623686 1406218 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleMicroinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study
ترجمه فارسی عنوان
مقالات ویژه متیفارفکتیک رایج ترین و شدیدا مربوط به زوال عقل در سالمندان قدیمی است: مطالعه 90+
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Microinfarct pathology is common in the oldest-old.
- Microinfarcts are strongly associated with dementia.
- Microinfarcts contribute independently and similarly in magnitude to dementia as tangle pathology.
- Only microinfarcts in cortical regions (other than occipital) are associated with dementia.

IntroductionWe estimated the prevalence of microinfarcts and their association with dementia in a cohort of oldest-old participants.MethodsParticipants were from The 90+ Study, a population-based study of people 90 years and older. Dementia diagnoses were assigned postmortem during a consensus conference. Microinfarcts were evaluated in six brain regions.ResultsAt death, the 213 participants were on average 97 years old, 69% were women, and 52% had dementia. Of the participants, 51% had microinfarcts and 17% had 3+ microinfarcts. The odds ratio (OR) for dementia was similar for 3+ microinfarcts (OR = 4.75, P < .01) and tangle stage V-VI (OR = 4.70, P < .001). Only microinfarcts in cortical regions (other than occipital) were associated to dementia.DiscussionIn this oldest-old cohort, microinfarcts are common and contribute independently and similarly in magnitude to dementia as tangles. As risk factors for microinfarcts and other dementing pathologies are likely to differ, identifying these factors is crucial to developing prevention strategies for dementia in the oldest-old.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 12, Issue 8, August 2016, Pages 900-908
نویسندگان
, , , ,