کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5623724 | 1406220 | 2016 | 10 صفحه PDF | دانلود رایگان |
IntroductionThe corticobasal syndrome (CBS) constitutes a neurodegenerative disease spectrum with substantial phenotypical or biological heterogeneity, requiring large or multimodal studies to identify its clinico-biological signature while disentangling Alzheimer's disease (AD)-related from non-AD-related CBS.MethodsWe analyzed a large (NÂ =Â 45) monocenter expert-clinic CBS cohort, recruited in motor and/or cognitive units to avoid recruitment biases, assessed with standardized motor and/or cognitive-language tests, brain perfusion imaging, and cerebrospinal fluid biomarkers.ResultsCBS mainly manifests as a motor and/or language disorder incorporating a “mixed progressive aphasia” phenotype, consistent with left-lateralized damage to frontal-parietal-temporal cortices. Biomarker expression indicates in 18% underlying AD causing predominant parietal-temporal damage and Gerstmann syndrome (sensitivity 75%; specificity 75%), whereas non-AD-CBS presented with predominant prefrontal and lexical-semantic impairment.DiscussionCBS is primarily a “motor-plus-aphasia” disease unfolding into AD-related and non-AD-related variants with distinctive cognitive-anatomic patterns. CBS, and notably its “Gerstmann variant”, should be included in the new AD “lexicon” and categorized in the evolving diagnostic spectrum of “atypical AD”d.
Journal: Alzheimer's & Dementia - Volume 12, Issue 7, July 2016, Pages 786-795