کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5624004 1406234 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleBenchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleBenchmarking biomarker-based criteria for Alzheimer's disease: Data from the Swedish Dementia Registry, SveDem
چکیده انگلیسی

IntroductionNew research guidelines for the diagnosis of Alzheimer's disease (AD) include biomarker evidence of amyloid-β (Aβ) and tau pathology. The aim of this study was to investigate what proportion of AD patients diagnosed in clinical routine in Sweden that had an AD-indicative cerebrospinal fluid (CSF) biomarker profile.MethodsBy cross-referencing a laboratory database with the Swedish Dementia Registry (SveDem), 2357 patients with data on CSF Aβ and tau biomarkers and a clinical diagnosis of AD with dementia were acquired.ResultsAltogether, 77.2% had pathologic Aβ42 and total tau or phosphorylated tau in CSF. These results were stable across age groups. Female sex and low mini-mental state examination score increased the likelihood of pathologic biomarkers.DiscussionAbout a quarter of clinically diagnosed AD patients did not have an AD-indicative CSF biomarker profile. This discrepancy may partly reflect incorrect (false positive) clinical diagnosis or a lack in sensitivity of the biomarker assays.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 12, December 2015, Pages 1470-1479
نویسندگان
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