کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5624359 1406247 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleSusceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors
ترجمه فارسی عنوان
نکات مهم در خصوص معیارهای معمول برای اختلال شناختی خفیف تا اشتباهات تشخیصی اشتباه
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

BackgroundWe assessed whether mild cognitive impairment (MCI) subtypes could be empirically derived within the Alzheimer's Disease Neuroimaging Initiative (ADNI) MCI cohort and examined associated biomarkers and clinical outcomes.MethodsCluster analysis was performed on neuropsychological data from 825 MCI ADNI participants.ResultsFour subtypes emerged: (1) dysnomic (n = 153), (2) dysexecutive (n = 102), (3) amnestic (n = 288), and (4) cluster-derived normal (n = 282) who performed within normal limits on cognitive testing. The cluster-derived normal group had significantly fewer APOE ε4 carriers and fewer who progressed to dementia compared with the other subtypes; they also evidenced cerebrospinal fluid Alzheimer's disease biomarker profiles that did not differ from the normative reference group.ConclusionsIdentification of empirically derived MCI subtypes demonstrates heterogeneity in MCI cognitive profiles that is not captured by conventional criteria. The large cluster-derived normal group suggests that conventional diagnostic criteria are susceptible to false-positive errors, with the result that prior MCI studies may be diluting important biomarker relationships.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 4, April 2015, Pages 415-424
نویسندگان
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