کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5633352 | 1581307 | 2017 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sleep disorders in neurologyFrench consensus. Type 1Â and type 2Â Narcolepsy: Investigations and follow-up Sleep disorders in neurologyFrench consensus. Type 1Â and type 2Â Narcolepsy: Investigations and follow-up](/preview/png/5633352.png)
In the new international classification of sleep disorders (ICSD-3), narcolepsy is differentiated into two distinct pathologies: type 1Â narcolepsy (NT1) and type 2Â narcolepsy (NT2). NT1Â is characterised by periods of an irrepressible need to sleep, cataplexy (a sudden loss of muscle tone triggered by emotion) and in some cases the presence of symptoms such as hypnagogic hallucinations, sleep paralysis and disturbed night-time sleep. Its physiopathology is based on the loss of hypocretin neurons in the hypothalamus, seemingly connected to an auto-immune process. By definition, cataplexy is absent and the hypocretin levels in the CSF are normal in NT2. Confirming the diagnosis requires polysomnography and multiple sleep latency tests. The choice of further investigations is based on the presence or absence of typical cataplexy. Further investigations include HLA typing, lumbar puncture to measure the hypocretin level in the CSF, or even brain imagery in the case of narcolepsy suspected to be secondary to an underlying pathology. In this consensus we propose recommendations for the work-up to be carried out during diagnosis and follow-up for patients suffering from narcolepsy.
Journal: Revue Neurologique - Volume 173, Issues 1â2, JanuaryâFebruary 2017, Pages 25-31