کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5642688 1586243 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New drug development in head and neck squamous cell carcinoma: The PI3-K inhibitors
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
New drug development in head and neck squamous cell carcinoma: The PI3-K inhibitors
چکیده انگلیسی


- Phosphatidylinositol 3-kinase (PI3-K) signaling plays a key role in tumorogenesis.
- The role of PI3-K inhibitors is being tested in head and neck cancer (HNC).
- This is the largest updated analysis of clinical trials in HNC patients.
- This analysis suggests that PI3-K inhibitors could influence outcomes in HNC.

Over the last few years a number of new different compounds have been developed. They include phosphatidylinositol 3-kinase (PI3-K) inhibitors. Deregulation within the PI3-K pathway is common in head neck squamous cell carcinoma (HNSCC) and it represents a growing area of research. PI3-K inhibitors, including BKM120, PX-866 and BYL719, are being tested in several phase I and phase II studies in patients with locally advanced, recurrent or metastatic disease.This review provides an update of published clinical trials and highlights the challenges of PI3-K inhibitors in HNSCC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Oral Oncology - Volume 67, April 2017, Pages 119-123
نویسندگان
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