کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5654999 1589418 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human γδ T cells: From a neglected lymphocyte population to cellular immunotherapy: A personal reflection of 30 years of γδ T cell research
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Human γδ T cells: From a neglected lymphocyte population to cellular immunotherapy: A personal reflection of 30 years of γδ T cell research
چکیده انگلیسی


- γδ T cells account for approximately 5% of CD3+ T cells in the blood and frequently express a Vγ9Vδ2 T-cell receptor
- Vγ9Vδ2 T cells recognize pyrophosphate molecules that are produced by bacteria but also by many tumor cells
- Vγ9Vδ2 T cells kill a broad variety of different tumor cells in an HLA-nonrestricted fashion
- Vγ9Vδ2 T cell activation and expansion can be manipulated pharmacologically, e.g. by nitrogen-containing bisphosphonates
- Vγ9Vδ2 T cells are attractive candiates for cellular immuotherapy

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 172, November 2016, Pages 90-97
نویسندگان
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