کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5670821 1592759 2017 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microbiological laboratory diagnostics of neglected zoonotic diseases (NZDs)
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Microbiological laboratory diagnostics of neglected zoonotic diseases (NZDs)
چکیده انگلیسی


- Anthrax.
- Bovine tuberculosis.
- Brucellosis.
- Echinococcosis.
- Leishmaniasis.
- Rabies.
- Taenia solium-associated diseases (neuro-/cysticercosis & taeniasis).
- Trypanosomiasis.

This review reports on laboratory diagnostic approaches for selected, highly pathogenic neglected zoonotic diseases, i.e. anthrax, bovine tuberculosis, brucellosis, echinococcosis, leishmaniasis, rabies, Taenia solium-associated diseases (neuro-/cysticercosis & taeniasis) and trypanosomiasis.Diagnostic options, including microscopy, culture, matrix-assisted laser-desorption-ionisation time-of-flight mass spectrometry, molecular approaches and serology are introduced. These procedures are critically discussed regarding their diagnostic reliability and state of evaluation. For rare diseases reliable evaluation data are scarce due to the rarity of samples.If bio-safety level 3 is required for cultural growth, but such high standards of laboratory infrastructure are not available, serological and molecular approaches from inactivated sample material might be alternatives.Multiple subsequent testing using various test platforms in a stepwise approach may improve sensitivity and specificity.Cheap and easy to use tests, usually called “rapid diagnostic tests” (RDTs) may impact disease control measures, but should not preclude developing countries from state of the art diagnostics.

According to the subjective opinion of the authors, the graphical abstract shows the importance of 4 different laboratory diagnostic approaches (microscopical-, cultural-, molecular biological- and serological approaches) for leishmaniasis, echinococcosis, cysticercosis, trypanosomiasis, tuberculosis, rabies, brucellosis and anthrax.161

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Tropica - Volume 165, January 2017, Pages 40-65
نویسندگان
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